Cancer is fundamentally a disease of tissue growth regulation caused by multiple genetic disorders. In order for a normal cell to transform into a cancer cell, the genes that regulate cell growth and differentiation must be altered specifically known as oncogenes, tumor-suppressor genes, and microRNA genes.
These alterations are usually somatic events occurring in somatic cells, although germ-line mutations that occur in sperm or ova can predispose a person to heritable or familial cancer. A single genetic change is rarely sufficient for the development of a malignant tumor. Most evidence points to a multistep process of sequential alterations in several, often many, oncogenes, tumor-suppressor genes or microRNA genes in cancer cells.
A liquid biopsy is a pan cancer genomic analysis done on a sample of blood to determine the presence of cancer tumor genes and their specific types of mutation from circulating tumor DNA(ctDNA). ctDNA is free flowing DNA from tumor cells found in the blood of cancer patients.Learn More
The Oncomine Myeloid Research Assay is a comprehensive, targeted Next-Generation Sequencing (NGS) assay designed to assist hematologists in the understanding of myeloid cancer. The assay is a complete kit facilitating the amplification of multiple gene targets from blood or bone marrow samples with as little as 10 ng of input DNA or RNA per pool.Learn More